Review of molecular signatures in older adults CD8+ T cells across human lifespan
Review of molecular signatures of T-cells in older adults antibody research
This post Reviews a journal article about reviews of molecular signatures of T-cells in older adults antibody research. Here is a link to the journal article. Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan
The article examines CD8+ T cells that provide antiviral immunity. The study suggests that priming T cells at different stages of life might greatly affect CD8+ T cell responses toward viral infections. Chiefly, they measure Molecular differentiation of A2/M158+CD8+ T cells across human lifespan in four age groups. Note – T cell receptor (TCR)
From the open article in Nature Immunology
One of the many graphical displays in the Journal article.
Review of molecular signatures of T-cells in older adults Journal article antibody research
Molecular differentiation of A2/M158+CD8+ T cells across human lifespan.
Why this study is important!
Understanding how we can preserve this delicate balance between expansion of ‘best-fit’ TCRs while maintaining TCR diversity may be the Holy Grail in defining how we can maintain optimal immunity across the human lifespan through vaccination and/or immunotherapies. The quick take away is this will help in treating aging, cancer and viruses in the future.
Note – This journal article requires both a statistical and Immunology background. In summary, this article has many visual graphs and data. However, the graphs are difficult to read and not well organized. Once more we run into the issues of poor science communication. If you can move past the reading issues, reviews of molecular signatures of T-cells in older adults antibody research